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Glide is a well-known ligand docking program developed by SCHRODINGER (http://www.schrodinger.com/productpage/14/5/). This tutorial describes how to dock a library of small ligands on an RNA receptor (also applicable to protein receptors). We will use both the ugly command-line approach and the graphical user interface maestro program throughout the docking procedure and we will see that there are advantages for both. This tutorial is for a docking beginner and you can refer to the online user manuals if you are seeking more details or flexibility for any step.